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CARE COVID-19 Study Information

The CARE Study: Characterizing Antibody Response to Emerging COVID-19

Online consent form

Consent can be completed online using the following link: 
Recruiting Participants

Blood and saliva samples are needed from health care workers and others in BC with known or suspected COVID-19 to validate antibody-testing strategies, to learn more about the antibody-specific immune response to COVID-19, and to inform public health decision-making

Background

To date, COVID-19 infection has been diagnosed primarily through laboratory tests that detect viral RNA. These diagnostic tests reveal whether someone is currently infected but do not reveal critical information about the development of immunity, which requires analysis of the antibodies generated by the immune system after infection. More information is urgently needed about the development, duration, and strength of the antibody responses that lead to immunity following COVID-19 infection.

This project will evaluate four new commercial antibody tests to determine which ones can reliably detect different types of antibodies that can provide clues about the immune response to COVID-19. These tests will be used to profile antibody production in both newly infected and previously infected health care workers and others over three months. Findings will reveal how quickly people develop an immune response and how robust this protection is against repeated exposures they may encounter after recovery. This antibody data can be used to immediately inform guidelines for essential workers at high risk of COVID-19 exposure, including return to work policies and front-line deployment strategies.

Who is conducting the study? 

UBC and BCCDC Project Leads: Muhammad Morshed, Inna Sekirov, Agatha Jassem

VCH Project Lead: Althea Hayden

BCCH Project Lead: David Goldfarb

UBC Collaborators: Victor Leung  (Providence Health Care) and Shazia Masud (Fraser Health Authority)

Funding: Genome BC Rapid Response Funding for COVID-19 Research and Innovation Projects, co-funded with BC Centre for Disease Control

Who can participate?

The study is looking for health care workers and others who are undiagnosed but eligible for COVID-19 testing (please see the self-assessment tool: https://bc.thrive.health/) due to recent onset of symptoms related to COVID-19.

The study is also looking for health care workers and others with confirmed COVID-19 diagnosis who have fully recovered from infection. 

Study volunteers must be over the age of 18 and reside in British Columbia. 

What is required to participate?

Volunteers must be willing to complete an online consent form or some individuals may consent when they present for diagnostic testing at participating collection sites.

COVID 19 positive individuals will be asked to submit blood and saliva samples, up to 7 visits over 3 months, at participating collection sites. 

Individuals who are determined to be negative for COVID-19 upon diagnostic testing will not have any follow-up testing performed.

Participants will be asked if they consent to researchers accessing routine medical information that is collected pertaining to COVID-19 infection (age, sex, symptoms, mode of transmission, test results, health care worker category, level of medical care required). 

Interested in enrolling? 

Contact the study team at CAREstudy@bccdc.ca or the principal investigator at Muhammad.morshed@bccdc.ca

Consent forms

Consent can be completed online using the following link: 
SOURCE: CARE COVID-19 Study Information ( )
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