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Pneumococcal Disease, invasive

Case definition

Confirmed case

Clinical evidence of invasive disease [1] with laboratory confirmation of infection:

  • Isolation of Streptococcus pneumoniae from a normally sterile site [2]; OR
  • Demonstration of S. pneumoniae DNA from a normally sterile site [2].


[1] Clinical illness associated with invasive disease manifests itself mainly as pneumonia with bacteremia, bacteremia without a known site of infection and meningitis. Pneumonia without bacteremia is not reportable.

[2] Normally sterile sites include: blood, CSF, pleural fluid, pericardial fluid, peritoneal fluid, bone or joint (synovial) fluid, deep tissue specimen taken during surgery. Excludes: middle ear and superficial wound aspirates, or specimens taken from infected areas/abscesses in sites following penetrating wounds.

SOURCE: Pneumococcal Disease, invasive ( )
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