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Case Definition

Confirmed Case

Clinical illness with laboratory confirmation of infection:

  • detection of IgM antibodies to Hantavirus
  • OR
  • detection of a significant (e.g. fourfold or greater) increase in hantavirus-specific IgG antibody titres
  • OR
  • detection of hantavirus-specific RNA in an appropriate clinical specimen
  • OR
  • detection of hantavirus antigen by immunohistochemistry

Probable Case

Clinical illness in a person who is epidemiologically linked to a confirmed case

Definition of clinical illness

  • Febrile illness (Temperature > 38.3° C [101° F] oral) requiring supplemental oxygen
  • PLUS
  • bilateral diffuse infiltrates (may resemble acute respiratory distress syndrome [ARDS])
  • PLUS
  • develops within 72 hours of hospitalization in a previously healthy person
  • OR
  • unexplained illness resulting in death plus an autopsy examination demonstrating non-cardiogenic pulmonary edema without an identifiable specific cause of death
SOURCE: Hantavirus ( )
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