Lab confirmation with clinical illness: Isolation of Leptospira sp in an appropriate specimen
A significant (e.g. fourfold or greater increase) in leptospira agglutination titre by microscopic agglutination test (MAT) using acute and convalescent sera taken at least 10 days apart
Definition of clinical illness
Clinical features include fever, headache, chills, muscle aches, vomiting, jaundice, anemia, and sometimes a rash. The incubation period usually is 7 days, with a range of 2-29 days. If not treated, the patient could develop kidney damage, meningitis, liver failure, and respiratory distress. In rare cases, death occurs.