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Case definition

Confirmed case

Clinical illness with laboratory confirmation of infection:

  • detection of viral antigen in an appropriate clinical specimen, preferably the brain or the nerves surrounding hair follicles in the nape of the neck, by immunofluorescence OR
  • isolation of rabies virus from saliva, cerebrospinal fluid or central nervous system tissue using cell culture or laboratory animal OR
  • detection of rabies virus RNA by PCR in an appropriate clinical specimen

Definition of clinical illness

Clinical illness is characterized by acute encephalomyelitis (headache, fever, hydrophobia, delirium, convulstions, paralysis) progressing to coma and death.

SOURCE: Rabies ( )
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