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Multi-system inflammatory syndrome in children and adolescents (MIS-C)


Children 0-19 years of age requiring hospitalization with fever for three days or more and two of the following:

a) Acute gastrointestinal symptoms (abdominal pain, vomiting, diarrhea);

b) Rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet);

c) Hypotension or shock;

d) Features of myocardial dysfunction or pericarditis or valvulitis or coronary abnormalities: ECHO

findings or elevated troponin/ brain natriuretic peptide (BNP)/ natriuretic peptide tests (NT-proBNP);

e) Evidence of coagulopathy: Abnormal prothrombin time/ partial thromboplastin time (PT/PTT), elevated d-dimer;


Elevated markers of inflammation such as erythrocyte sedimentation rate, C-reactive protein, or procalcitonin;


No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal or streptococcal shock syndromes, and no alternative plausible obvious diagnosis;


Evidence of SARS-CoV-2 infection (positive NAAT test, antigen test and/or serology) or close contact1 with a confirmed or probable (lab-probable or epi-link probable) COVID-19 case2

1 Close contacts include individuals who lived with or had close contact (within two metres) with a COVID-19

case for more than 15 minutes up to 48 hours prior to symptom onset. Refer to the BCCDC for a full definition of close contacts.

2 Refer to the BCCDC for further information on confirmed and lab-probable COVID-19 cases.


SOURCE: Multi-system inflammatory syndrome in children and adolescents (MIS-C) ( )
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