Children and adolescents 0-19 years of age requiring hospitalization with fever ≥ 3 days
AND two of the following:
a) Acute gastrointestinal symptoms (abdominal pain, vomiting, diarrhoea)
b) Rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet)
c) Hypotension or shock
d) Features of myocardial dysfunction, or pericarditis, or valvulitis, or coronary abnormalities (ECHO findings or elevated Troponin/BNP/NT-proBNP)
e) Evidence of coagulopathy (abnormal PT, PTT, elevated d-dimer)
AND Elevated markers of inflammation such as ESR, C-reactive protein, or procalcitonin
AND No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal or streptococcal shock syndromes, or no alternative plausible obvious diagnosis.
MIS-C person under investigation AND evidence of SARS-CoV-2 infection (positive PCR test or serology), or close contact1 with a confirmed or probable (lab-probable or epi-link probable) COVID-19 case2.
Close contacts include individuals who lived with or had close contact (within 2m) with a COVID case for more than 15min up to 48h prior to symptom onset. See a full definition
of close contacts.
Confirmed and lab-probable cases have positive or indeterminate NAAT results, respectively. COVID-19 cases are further defined here