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Multi-system inflammatory syndrome in children and adolescents (MIS-C)

Person under investigation

Children and adolescents 0-19 years of age requiring hospitalization with fever ≥ 3 days 

AND two of the following:

a) Acute gastrointestinal symptoms (abdominal pain, vomiting, diarrhoea)

b) Rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet) 

c) Hypotension or shock

d) Features of myocardial dysfunction, or pericarditis, or valvulitis, or coronary abnormalities (ECHO findings or elevated Troponin/BNP/NT-proBNP)

e) Evidence of coagulopathy (abnormal PT, PTT, elevated d-dimer)

AND Elevated markers of inflammation such as ESR, C-reactive protein, or procalcitonin 

AND No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal or streptococcal shock syndromes, or no alternative plausible obvious diagnosis.


MIS-C person under investigation AND evidence of SARS-CoV-2 infection (positive PCR test or serology), or close contact1 with a confirmed or probable (lab-probable or epi-link probable) COVID-19 case2.
Close contacts include individuals who lived with or had close contact (within 2m) with a COVID case for more than 15min up to 48h prior to symptom onset. See a full definition of close contacts. 

2 Confirmed and lab-probable cases have positive or indeterminate NAAT results, respectively. COVID-19 cases are further defined here.   
SOURCE: Multi-system inflammatory syndrome in children and adolescents (MIS-C) ( )
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