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Meningococcal Disease, Invasive

 
 

Case definition

Confirmed case

Clinical evidence* of invasive disease with laboratory confirmation of infection:

  • isolation of N. meningitidis from a normally sterile site (blood, CSF, joint, pleural or pericardial fluid) 
OR

  • demonstration of N. meningitidis DNA by an appropriately validated nucleic acid test (NAT) from a normally sterile site. 

Probable case

Clinical evidence* of invasive disease with purpura fulminans or meningococcemia, with no other apparent cause, with non-confirmatory laboratory evidence:

  • Gram-negative diplococci in the CSF

* Clinical illness associated with invasive meningococcal disease usually manifests as meningitis and/or septicaemia, although other manifestations may be observed (e.g., orbital cellulitis, septic arthritis). Invasive disease may progress rapidly to purpura fulminans, shock and death.

Definition of clinical illness

Clinical illness associated with invasive meningococcal disease usually manifests itself as meningitis and/or septicaemia, although other manifestations may be observed (e.g. orbital cellulitis, septic arthritis). Invasive disease may progress rapidly to petechiae or purpura fulminans, shock and death.

SOURCE: Meningococcal Disease, Invasive ( )
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