- Two clinicaly compatible manifestations from List A  or List B  with laboratory confirmation of infection by:
- Isolation of rubella virus from an appropriate clinical specimen; OR
- Detection of rubella virus RNA; OR
- Positive serologic test for rubella IgM antibody in the absence of recent immunization with rubella-containing vaccine; OR
- Rubella IgG persisting for longer than would be expected (approximately 6 months following birth) from passive transfer of maternal antibody, or in the absence of recent immunization.
- Two clinically compatible manifestations [1,2] with detection of rubella virus from an appropriate post mortem specimen.
- In the absence of appropriate laboratory tests, a case that has at least:
- Any two clinically compatible manifestations listed in List A ; OR
- One manifestation in List A  and one in List B .
1. Clinically Compatible Manifestations: List A
- Cataract or congenital glaucoma (either one or both count as one)
- Congenital heart defect
- Sensorineural hearing loss
- Pigmentary retinopathy
2. Clinically Compatible Manifestations: List B
- Micro opthalmia
- Mental retardation
- Radiolucent bone disease
- Development or late onset conditions such as diabetes and progressive panencephalitis and any other conditions possibly caused by rubella virus