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Rubella, Congenital Syndrome (CRS)

Case Definition

Confirmed Case

Live Birth
  • Two clinicaly compatible manifestations from List A [1] or List B [2] with laboratory confirmation of infection by:
    • Isolation of rubella virus from an appropriate clinical specimen; OR
    • Detection of rubella virus RNA; OR
    • Positive serologic test for rubella IgM antibody in the absence of recent immunization with rubella-containing vaccine; OR
    • Rubella IgG persisting for longer than would be expected (approximately 6 months following birth) from passive transfer of maternal antibody, or in the absence of recent immunization.
  • Two clinically compatible manifestations [1,2] with detection of rubella virus from an appropriate post mortem specimen.

Probable Case

  • In the absence of appropriate laboratory tests, a case that has at least:
    • Any two clinically compatible manifestations listed in List A [1]; OR
    • One manifestation in List A [1] and one in List B [2].

1. Clinically Compatible Manifestations: List A

  • Cataract or congenital glaucoma (either one or both count as one)
  • Congenital heart defect
  • Sensorineural hearing loss
  • Pigmentary retinopathy

2. Clinically Compatible Manifestations: List B

  • Purpura
  • Hepatosplenomegaly
  • Microcephaly
  • Micro opthalmia
  • Mental retardation
  • Meningoencephalitis
  • Radiolucent bone disease
  • Development or late onset conditions such as diabetes and progressive panencephalitis and any other conditions possibly caused by rubella virus

SOURCE: Rubella, Congenital Syndrome (CRS) ( )
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