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Rubella, Congenital Infection (CRI)

Case Definition

Confirmed Case

Laboratory confirmation of infection but with no clinically compatible manifestations [1]:  

  • Isolation of rubella virus from an appropriate clinical specimen; OR
  • Detection of rubella virus RNA; OR
  • Positive serologic test for rubella IgM antibody in the absence of recent immunization with rubella-containing vaccine; OR
  • Rubella IgG persisting for longer than would be expected (approximately 6 months after birth) from passive transfer of maternal antibody, or in the absence of recent immunization.

1. Definition of clinically compatible manifestations

  • Cataracts or congenital glaucoma (either one or both count as one)
  • Congenital heart defect
  • Sensorineural hearing loss
  • Pigmentary retinopathy
  • Purpura
  • Hepatosplenomegaly
  • Microcephaly
  • Micro opthalmia
  • Mental retardation
  • Meningoencephalitis
  • Radiolucent bone disease
  • Developmental or late onset conditions such as diabetes and progressive panencephalitis and any other conditions possibly caused by rubella virus.

SOURCE: Rubella, Congenital Infection (CRI) ( )
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