A person who is laboratory confirmed for monkeypox virus by detection of unique sequences of viral DNA either by real-time polymerase chain reaction (PCR) and/or sequencing.
A person of any age who presents with an unexplained1 acute rash or lesion(s)2
Has one or more of the following:
- Has an epidemiological link to a probable or confirmed monkeypox case in the 21 days before symptom onset, such as
- face-to-face exposure, including health workers without appropriate personal protective equipment (PPE)
- direct physical contact, including sexual contact; or contact with contaminated materials such as clothing or bedding
- Reported travel history to or residence in a location where monkeypox is reported3 in the 21 days before symptom onset
A person of any age who presents with one or more of the following:
- An unexplained1 acute rash2 AND has at least one of the following signs or symptoms
- acute onset of fever (>38.5°C)
- lymphadenopathy (swollen lymp nodes)
- back pain
- asthenia (profound weakness)
- An unexplained1 acute genital, perianal or oral lesion(s)
1. Common causes of acute rash can include varicella zoster, herpes zoster, measles, herpes simplex, syphilis, chancroid, lymphogranuloma venereum, hand-foot-and-mouth disease.
2. Acute rash
Monkeypox illness includes a progressively developing rash that usually starts on the face and then spreads elsewhere on the body. The rash can affect the mucous membranes in the mouth, tongue, and genitalia. The rash can also affect the palms of hands and soles of the feet. The rash can last 2 to 4 weeks and progresses through the following stages before falling off:
N.B. It is not necessary to obtain negative laboratory results for listed common causes of rash illness in order to classify a case as suspected.
3. Reported travel history includes regional, national, or international travel in the 21 days before symptom onset to any area where monkeypox may be reported.