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Dengue

Case Definition

Confirmed Case

A case with clinically compatible signs and symptoms and at least two of the following hemorrhagic manifestations1:

  • hemorrhagic or purpuric rash
  • epistaxis
  • hematemesis
  • hemoptysis
  • blood in stools
  • other hemorrhagic symptom and no known predisposing host factors for hemorrhagic manifestations
AND

Laboratory confirmation of infection by one of the following methods:

  • Isolation of dengue virus from an appropriate clinical specimen (blood, serum, tissue, urine specimens, or throat secretions)
  • Detection of dengue virus nucleic acid by reverse-transcriptase PCR from blood, serum, or tissue
  • Demonstration of dengue virus antigen in tissue (skin, liver, or spleen) by immunohistochemical or immunofluorescent techniques
  • Demonstration of a significant (e.g. fourfold or greater rise) change in dengue virus neutralizing antibody titres in paired acute and convalescent sera by EIA, immunofluorescent assay, or Western Blot
  • Demonstration of seroconversion of IgG or IgM antibodies by EIA, immunofluorescent assay, or Western Blot
  • Demonstration of dengue virus antigen in blood, serum, or tissue by enzyme immunoassay (EIA ELISA)

Probable Case

A case with clinically compatible signs and symptoms and at least two of the following hemorrhagic manifestations1:

  • hemorrhagic or purpuric rash
  • epistaxis
  • hematemesis
  • hemoptysis
  • blood in stools
  • other hemorrhagic symptom and no known predisposing host factors for hemorrhagic manifestations
AND

Demonstration of a single elevated antibody titre by EIA, immunofluorescent assay or Western Blot

 

Notes:

  1. Only cases with hemorrhagic presentations are reportable.







SOURCE: Dengue ( )
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