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Streptococcus pneumonia, invasive

Case definition

Confirmed case

Clinical evidence of invasive disease with laboratory confirmation of infection:

  • Isolation of Streptococcus pneumoniae from a normally sterile site (excluding the middle ear); OR
  • Demonstration of S. pneumoniae DNA from a normally sterile site (excluding the middle ear).

Probable case

Clinical evidence of invasive disease and no other apparent cause and with non-confirmatory laboratory evidence:

  • Demonstration of S. pneumoniae antigen from a normally sterile site (excluding the middle ear).

Definition of clinical illness

Clinical illness associated with invasive disease manifests itself mainly as pneumonia with bacteremia, bacteremia without a known site of infection and meningitis. Pneumonia without bacteremia is not reportable.

SOURCE: Streptococcus pneumonia, invasive ( )
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